MDRTBTx-Monitor

Evaluation of alternative bacteriological measures of response to therapy during the initial 16 weeks of MDR-TB treatment [MDRTBTx-Monitor]

Duration (months)

EDCTP Budget Total (€)

COORDINATOR

149750.00

Makerere University

Uganda

Dr Willy Ssengooba

Background

Effective treatment monitoring is vital not only for proper patient management but also for preventing the unnecessary continuation of failing treatment and the emergence of more drug-resistant M. tuberculosis (Mtb).

What did we do?

In a prospective study of 59 patients, ≥ 18 years of age with MDR/RR-TB and started on MDR-TB treatment short-regimen. Two sputum samples, a spot, and overnight were taken at weeks 0, 2, 4, 6, 8, 12, and 16 of MDR-TB treatment.

What did we find out?

Of the 59 participants enrolled, one did not provide sputum samples at baseline. The analysis is based on 58 participants who provided baseline sputum samples. There were more male 37 (63.8) than female participants.

Grant code	TMA2018CDF-2351
Periodic report	4
Period covered by report	01 November 2022 to 30 April 2023
Start date of the action	01/11/2019
End date of the action	30/04/2023
Version and date of report	Version 1.0 29^thJune 2023
The report is elaborated on the basis of the: Original or amended grant agreement	Amended Grant Agreement)

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<a href="https://sbs.mak.ac.ug/summary-bsc-msc-ph-d-and-research-fellows">MSc Fellows</a>

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<a href="https://sbs.mak.ac.ug/summary-bsc-msc-ph-d-and-research-fellows">Junior & Ph.D Fellows</a>

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<a href="/mdrtbtx-monitor/contributions-and-books">Books Contributions</a>

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<a href="https://sbs.mak.ac.ug/mdrtbtx-monitor/mdrtbtx-monitor-publications">Publications</a>

Tesimonials

Contribution to COVID-19 pandemic control

I was tasked to join the team as a technical expert to set up the Xpert Xpress SARS-CoV-2 testing at Malaba border point: which I did on 11/May/2020 and later at Mutukula border point on 15^th -16^th May 2020.

Willy Ssengooba

Ph.D

On 26^th May 2020, I received a request from the Commissioner National Health Laboratory and Diagnostic Services to conduct a biosafety assessment and training at ELEGU border point which I completed on 27^th May 2020. We published 3 COVID-19 related articles for publication.